Tumour Genetic Heterogeneity in Relation to Oral Squamous Cell Carcinoma and Anti-Cancer Treatment

Gal Feller, Razia Abdool Gafaar Khammissa*, Raoul Ballyram, Mia Michaela Beetge, Johan Lemmer, Liviu Feller

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Oral squamous cell carcinoma (SCC) represents more than 90% of all oral cancers and is the most frequent SCC of the head and neck region. It may affect any oral mucosal subsite but most frequently the tongue, followed by the floor of the mouth. The use of tobacco and betel nut, either smoked or chewed, and abuse of alcohol are the main risk factors for oral SCC. Oral SCC is characterized by considerable genetic heterogeneity and diversity, which together have a significant impact on the biological behaviour, clinical course, and response to treatment and on the generally poor prognosis of this carcinoma. Characterization of spatial and temporal tumour-specific molecular profiles and of person-specific resource availability and environmental and biological selective pressures could assist in personalizing anti-cancer treatment for individual patients, with the aim of improving treatment outcomes. In this narrative review, we discuss some of the events in cancer evolution and the functional significance of driver-mutations in carcinoma-related genes in general and elaborate on mechanisms mediating resistance to anti-cancer treatment.

Original languageEnglish
Article number2392
JournalInternational Journal of Environmental Research and Public Health
Volume20
Issue number3
DOIs
Publication statusPublished - Feb 2023

Keywords

  • cancer-evolution
  • driver mutation
  • genetic diversity
  • genetic heterogeneity
  • natural selection
  • oral squamous cell carcinoma
  • passenger mutation
  • resistance to anti-cancer treatment

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