TY - JOUR
T1 - Two hispidin dimers from Piptoporellus baudonii (Fomitopsidaceae) with anticancer activity
AU - Kuete, Jenifer Reine Ngnouzouba
AU - Fadeyi, Olyvia Gwladys
AU - Olou, Boris Armel
AU - Kenmoe, Frank Wilson Tiatsop
AU - Tsakem, Bienvenu
AU - Teponno, Rémy Bertrand
AU - Tapondjou, Léon Azefack
AU - Kouam, Simeon Fogue
AU - Yorou, Nourou Soulemane
N1 - Publisher Copyright:
© 2024 Phytochemical Society of Europe
PY - 2025/2
Y1 - 2025/2
N2 - Chemical analysis of the ethanol extract from the stromata of Piptoporellus baudonii led to the isolation and characterization of two unreported bishispidin derivatives named 11-hydroxysquarrosidine (1) and laetipohispidin (2) together with two known terpenoids: ergosterol (3) and eburicoic acid (4). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR, UV, IR, ECD as well as the high-resolution mass spectrometry. Although metabolite 1 was reported in a patent as a synthetic compound, this is the first report on its isolation from natural source. Compounds 1 and 2 were evaluated for their antimicrobial and cytotoxic activities. 11-hydroxysquarrosidine (1) exhibited a moderate activity against all the tested human cancer cell lines with IC50 values ranging from 25.79 to 73.41 µM.
AB - Chemical analysis of the ethanol extract from the stromata of Piptoporellus baudonii led to the isolation and characterization of two unreported bishispidin derivatives named 11-hydroxysquarrosidine (1) and laetipohispidin (2) together with two known terpenoids: ergosterol (3) and eburicoic acid (4). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR, UV, IR, ECD as well as the high-resolution mass spectrometry. Although metabolite 1 was reported in a patent as a synthetic compound, this is the first report on its isolation from natural source. Compounds 1 and 2 were evaluated for their antimicrobial and cytotoxic activities. 11-hydroxysquarrosidine (1) exhibited a moderate activity against all the tested human cancer cell lines with IC50 values ranging from 25.79 to 73.41 µM.
KW - Antimicrobial activity
KW - Cytotoxic activity
KW - Hispidin derivatives
KW - Piptoporellus baudonii
UR - https://www.scopus.com/pages/publications/85209129980
U2 - 10.1016/j.phytol.2024.11.002
DO - 10.1016/j.phytol.2024.11.002
M3 - Article
AN - SCOPUS:85209129980
SN - 1874-3900
VL - 65
SP - 19
EP - 23
JO - Phytochemistry Letters
JF - Phytochemistry Letters
ER -
