Venom of a six-eyed crab spider, Sicarius testaceus (Purcell, 1908), causes necrotic and haemorrhagic lesions in the rabbit

G. Van Aswegen; J. M. Van Rooyen; D. G. Van Der Nest; Frederick Johannes Veldman; T. H. De Villiers; G. Oberholzer

doi:10.1016/S0041-0101(96)00203-6

Venom of a six-eyed crab spider, Sicarius testaceus (Purcell, 1908), causes necrotic and haemorrhagic lesions in the rabbit

G. Van Aswegen^*, J. M. Van Rooyen, D. G. Van Der Nest, Frederick Johannes Veldman, T. H. De Villiers, G. Oberholzer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

By employing haematological, histological and isotope studies on rabbit, it was shown that envenomation by the South African crab spider, Sicarius testaceus, results in tissue necrosis and a marked increase in the permeability of the blood vessels in the vicinity of envenomation. The venom also acts systemically, which results in petechial bleeding of some viscera, thrombocytopaenia and elevated fibrinogen levels. Rabbit envenomation by this species results in a dramatic drop of the platelet count, without haemolytic anaemia. Should these parameters be the same in humans, they may serve as a yardstick to distinguish presumptive S. testaceus envenomation from that of Loxosceles.

Original language	English
Pages (from-to)	1149-1152
Number of pages	4
Journal	Toxicon
Volume	35
Issue number	7
DOIs	https://doi.org/10.1016/S0041-0101(96)00203-6 https://doi.org/10.1016/S0041-0101(96)00203-6
Publication status	Published - 1 Jul 1997
Externally published	Yes

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title = "Venom of a six-eyed crab spider, Sicarius testaceus (Purcell, 1908), causes necrotic and haemorrhagic lesions in the rabbit",

abstract = "By employing haematological, histological and isotope studies on rabbit, it was shown that envenomation by the South African crab spider, Sicarius testaceus, results in tissue necrosis and a marked increase in the permeability of the blood vessels in the vicinity of envenomation. The venom also acts systemically, which results in petechial bleeding of some viscera, thrombocytopaenia and elevated fibrinogen levels. Rabbit envenomation by this species results in a dramatic drop of the platelet count, without haemolytic anaemia. Should these parameters be the same in humans, they may serve as a yardstick to distinguish presumptive S. testaceus envenomation from that of Loxosceles.",

author = "{Van Aswegen}, G. and {Van Rooyen}, {J. M.} and {Van Der Nest}, {D. G.} and Veldman, {Frederick Johannes} and {De Villiers}, {T. H.} and G. Oberholzer",

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T1 - Venom of a six-eyed crab spider, Sicarius testaceus (Purcell, 1908), causes necrotic and haemorrhagic lesions in the rabbit

AU - Van Aswegen, G.

AU - Van Rooyen, J. M.

AU - Van Der Nest, D. G.

AU - Veldman, Frederick Johannes

AU - De Villiers, T. H.

AU - Oberholzer, G.

PY - 1997/7/1

Y1 - 1997/7/1

N2 - By employing haematological, histological and isotope studies on rabbit, it was shown that envenomation by the South African crab spider, Sicarius testaceus, results in tissue necrosis and a marked increase in the permeability of the blood vessels in the vicinity of envenomation. The venom also acts systemically, which results in petechial bleeding of some viscera, thrombocytopaenia and elevated fibrinogen levels. Rabbit envenomation by this species results in a dramatic drop of the platelet count, without haemolytic anaemia. Should these parameters be the same in humans, they may serve as a yardstick to distinguish presumptive S. testaceus envenomation from that of Loxosceles.

AB - By employing haematological, histological and isotope studies on rabbit, it was shown that envenomation by the South African crab spider, Sicarius testaceus, results in tissue necrosis and a marked increase in the permeability of the blood vessels in the vicinity of envenomation. The venom also acts systemically, which results in petechial bleeding of some viscera, thrombocytopaenia and elevated fibrinogen levels. Rabbit envenomation by this species results in a dramatic drop of the platelet count, without haemolytic anaemia. Should these parameters be the same in humans, they may serve as a yardstick to distinguish presumptive S. testaceus envenomation from that of Loxosceles.

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DO - 10.1016/S0041-0101(96)00203-6

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SN - 0041-0101

VL - 35

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JO - Toxicon

JF - Toxicon

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ER -

Venom of a six-eyed crab spider, Sicarius testaceus (Purcell, 1908), causes necrotic and haemorrhagic lesions in the rabbit

Abstract

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