Vitamin D supplementation in a post-pandemic era: A narrative review

Pheagane G. Bopape*, Chrisna Wagenaar, Madan Poka, Elmien Bronkhorst

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Vitamin D is a fat-soluble molecule referring to the different isoforms, ergocalciferol (D2) and cholecalciferol (D3). Its physiological functions include increasing calcium serum concentrations. 25-hydroxyvitamin D3 (25(OH)D) (Calcifediol), a non-active, circulating instant precursor is seen as a pre-hormone. Studies have shown that a deficiency in calcifediol is related to chronic conditions such as cardiovascular, musculoskeletal, immune system, neurological, and anti-neoplastic functions. Vitamin D supplementation has shown its benefit as prophylaxis and treatment during the coronavirus disease 2019 (COVID-19) pandemic and an increase in the prescribing of vitamin D supplementation has been observed. The intention of this review article is to provide guidance on the recommended dosage regimen as a prophylactic measure during COVID-19 and its use as a supplement in general. From this review article, it is clear that vitamin D has an important role to play not only in COVID-19 but also in various other health aspects of the human body. Contribution: This review article highlighted the role of vitamin D in managing vitamin D deficiency and its role as a supplement in the management of respiratory tract infections, especially COVID-19. This overview can assist physicians in optimising healthcare by optimised dosing recommendations and indications.

Original languageEnglish
Article numbera5752
JournalSouth African Family Practice
Issue number1
Publication statusPublished - 2023


  • COVID-19
  • Calcifediol
  • Cholecalciferol
  • Chronic diseases
  • Deficiency
  • Vitamin D


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