@article{41f693a8511f445f951b5769fe55344b,
title = "Whole genome analysis of human rotaviruses reveals single gene reassortant rotavirus strains in zambia",
abstract = "Rotarix{\textregistered} vaccine was implemented nationwide in Zambia in 2013. In this study, four unusual strains collected in the post-vaccine period were subjected to whole genome sequencing and analysis. The four strains possessed atypical genotype constellations, with at least one reassortant genome segment within the constellation. One of the strains (UFS-NGS-MRC-DPRU4749) was ge-netically and phylogenetically distinct in the VP4 and VP1 gene segments. Pairwise analyses demonstrated several amino acid disparities in the VP4 antigenic sites of this strain compared to that of Rotarix{\textregistered}. Although the impact of these amino acid disparities remains to be determined, this study adds to our understanding of the whole genomes of reassortant strains circulating in Zambia following Rotarix{\textregistered} vaccine introduction.",
keywords = "Amino acid, Genotype constellation, Intergenogroup reassortment, Rotarix{\textregistered}, Rotavirus, Whole genome",
author = "Maringa, {Wairimu M.} and Julia Simwaka and Mwangi, {Peter N.} and Mpabalwani, {Evans M.} and Mwenda, {Jason M.} and Mphahlele, {M. Jeffrey} and Seheri, {Mapaseka L.} and Nyaga, {Martin M.}",
note = "Funding Information: This research was primarily funded by a WHO grant awarded to M.M.N (agreement number UFS-AGR-000378). Additional grants from the Bill and Melinda Gates Foundation (BMGF-OPP1180423_2017), the South African Medical Research Foundation through the Self-Initiated Research grant, the National Research Foundation (NRF-120814) and the Poliomyelitis Research Foundation (PRF-19/16) awarded to M.M.N also supported this research. The views and opinions ex-pressed in this article do not reflect those of the funders and affiliated institutions, but rather those of the authors of this publication. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = sep,
doi = "10.3390/v13091872",
language = "English",
volume = "13",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "9",
}